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Do certain diets tend to correlate with certain outcomes? There are really three components of diet that seems to be impacting aging: So the first is how much we eat, the second is what we eat, and the third is when we eat. So in terms of how much we eat, a lot of science went into this idea of ​​caloric restriction. Caloric restriction isn't starvation. It's usually just about a 20% reduction in the overall calorie intake. In a lot of different animal models, so anything from a worm, fly, mouse, people have seen that when animals are caloric restricted, they tend to live longer. When trying to figure out if something like caloric restriction is actually beneficial to the aging process in terms of slowing aging, one caveat is that humans today are not at baseline; we're actually more prone to overeating. So some researchers have figured out that it might not be the caloric restriction that's actually the beneficial. So even if you can't restrict your calories, just moving away from overeating is probably gonna have a beneficial effect for most people.

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Do / certain diets / tend to correlate / with certain outcomes? // There are really / three components / of diet / that seem to be impacting aging: // So the first is / how much we eat, / the second / is what we eat, / and the third is / when we eat. // So in terms of / how much we eat, / a lot of science went into this idea / of ​​caloric restriction. // Caloric restriction / isn't / starvation. // It's usually / just about a 20% reduction / in the overall calorie intake. // In a lot of different / animal models, / so / anything from / a worm, / fly, / mouse, / people have seen / that / when animals are caloric restricted, / they tend to live longer. // When trying to figure out if / something like / caloric restriction / is actually beneficial / to the aging process / in terms of slowing aging, / one caveat / is that / humans today / are not at baseline; // we're actually / more prone / to overeating. // So some researchers / have figured out / that it / might not be / the caloric restriction / that's actually / the beneficial thing. / So // even if / you can't / restrict / your calories, / just / moving away / from overeating / is probably gonna have a beneficial effect / for most people. //

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The other thing that's been studied is this concept of what we eat. A lot of research has gone into whether things like a plant-based diet are actually beneficial to aging and longevity. And there seems to be some evidence that eating less animal products, more fruits and veggies, more whole foods is gonna be better overall; and also minimizing things like refined sugars, and the things that we know are bad for our health. The third comes down to when we eat, and this is really a new field in aging and longevity science. So again, most people aren't gonna be able to calorically restrict, but what scientists found is actually fasting can mimic some of the benefits that we've seen with caloric restriction. So if people can perhaps minimize their eating to a small window, we think that this can actually recapitulate a lot of the benefits that we're seeing in the caloric restriction studies. The idea of why things like caloric restriction or fasting might actually improve our aging process is because we think this evokes this idea of 'hormesis' in our bodies. What hormesis refers to is a mild stressor that actually makes our bodies more resilient and robust to stress over time. So having these short-term mild stressors, whether it be fasting or whether it be a small caloric deficit, actually makes our bodies more resilient against a lot of the changes we see that increase with aging.

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The other thing / that's been studied / is this / concept of / what we eat. // A lot of / research has gone into / whether things / like a plant-based diet / are actually / beneficial / to aging / and longevity. // And there seems to be / some evidence / that eating less / animal products, / more fruits / and veggies, / more whole foods / is gonna be / better overall; // and / also / minimizing things / like / refined sugars, / and / the things / that we know / are bad / for our health. // The third // comes down / to / when we eat, / and this is / really / a / new field / in aging / and longevity science. // So // again, / most people / aren't gonna be able to / calorically restrict, / but what / scientists found / is actually / fasting can mimic / some of the benefits / that we've seen with caloric restriction. // So if / people can / perhaps / minimize their eating / to a small window, // we think / that this can actually / recapitulate / a lot of the benefits / that we're seeing / in the / caloric restriction studies. // The idea/ of ​​why / things like / caloric restriction / or fasting / might actually / improve / our aging process / is because / we think / this evokes / this idea of / 'hormesis' / in our bodies. // What hormesis / refers to / is a mild stressor / that actually / makes our bodies more resilient / and robust / to stress over time. // So having / these short-term / mild stressors, / whether it be fasting / or whether it be / a small / caloric deficit, / actually makes our bodies / more resilient against / a lot of the changes we see / that increase with aging. //